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ESKAFAN FORTE tablets contain artemether, lumefantrine which are blood
schizonticides. Artemether is a Synthetic antimalarial derived from artemisinin.
Mechanism of action, involves an interaction with ferriprotoporphyrin IX (“heme”), or
ferrous ions, in the acidic parasite food vacuole, which results in the generation of
cytotoxic radical species. The generally accepted mechanism of action of peroxide
antimalarials involves interaction of the peroxide-containing drug with heme, a
hemoglobin degradation by product, derived from proteolysis of hemoglobin. This
interaction is believed to result in the formation of a range of potentially toxic oxygen and
carbon-centered radicals.
Technical Details:
| Expiry date: | 2024-12-31 |
|---|---|
| Seller SKU: | FV101 |
| Availability: | In Stock |
| Minimum order quantity: | 2170 |
| Date first listed on TopazMed: | Sep 20, 2022 |
ESKAFAN FORTE tablets contain artemether, lumefantrine which are blood
schizonticides. Artemether is a Synthetic antimalarial derived from artemisinin.
Mechanism of action, involves an interaction with ferriprotoporphyrin IX (“heme”), or
ferrous ions, in the acidic parasite food vacuole, which results in the generation of
cytotoxic radical species. The generally accepted mechanism of action of peroxide
antimalarials involves interaction of the peroxide-containing drug with heme, a
hemoglobin degradation by product, derived from proteolysis of hemoglobin. This
interaction is believed to result in the formation of a range of potentially toxic oxygen and
carbon-centered radicals.
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